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Chemical structure of IRAK4-IN-6

GC61944

IRAK4-IN-6

Also known as methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma

ChemicalCAS2454244-02-9MW504.59FormulaC25H32N10O2
CAS number
2454244-02-9
Molecular weight
504.59
Formula
C25H32N10O2
Solubility
DMSO ： 125 mg/mL (247·73 mM)
InChIKey
RPGMSHCJIWHISY-UHFFFAOYSA-N
Catalogue number
GC61944
Brand
GLPBIO
Computed properties PubChem CID 139582017 · XLogP 1.8 · TPSA 137 Ų · H-bond donors 2
XLogP
1.8
TPSA
137 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
37

SMILES CN1C=C(C=N1)NC2=NC3=C(C(=N2)NC4CCC(CC4)N5CCN(CC5)C(=O)OC)N=C(C=C3)CC#N

Computed descriptors from PubChem (CID 139582017), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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