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Chemical structure of PF-4618433

GC61852

PF-4618433

Also known as 1-[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]-3-[5-(pyridin-3-yloxymethyl)-1H-pyrazol-3-yl]urea

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM

ChemicalCAS1166393-85-6MW445.52FormulaC24H27N7O2
CAS number
1166393-85-6
Molecular weight
445.52
Formula
C24H27N7O2
Solubility
DMSO ： 125 mg/mL (280·57 mM)
InChIKey
NJARPUHZDSAXPL-UHFFFAOYSA-N
Catalogue number
GC61852
Brand
GLPBIO
Computed properties PubChem CID 25203958 · XLogP 3.9 · TPSA 110 Ų · H-bond donors 3
XLogP
3.9
TPSA
110 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
7
Heavy atoms
33

SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=NNC(=C3)COC4=CN=CC=C4

Computed descriptors from PubChem (CID 25203958), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.