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Chemical structure of PF-4191834

GC36883

PF-4191834

Also known as 4-[3-[4-(2-methylpyrazol-3-yl)phenyl]sulfanylphenyl]oxane-4-carboxamide

PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain

ChemicalCAS1029317-21-2MW393.5FormulaC22H23N3O2S
CAS number
1029317-21-2
Molecular weight
393.5
Formula
C22H23N3O2S
Solubility
Soluble in DMSO
InChIKey
DVNQWYLVSNPCJZ-UHFFFAOYSA-N
Catalogue number
GC36883
Brand
GLPBIO
Computed properties PubChem CID 24986635 · XLogP 3 · TPSA 95.4 Ų · H-bond donors 1
XLogP
3
TPSA
95.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
28

SMILES CN1C(=CC=N1)C2=CC=C(C=C2)SC3=CC=CC(=C3)C4(CCOCC4)C(=O)N

Computed descriptors from PubChem (CID 24986635), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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