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Chemical structure of APS6-45

GC60592

APS6-45

Also known as 4-[4-[[2-fluoro-5-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide

APS6-45 is an orally active tumor-calibrated inhibitor (TCI)· APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity

ChemicalCAS2188236-41-9MW548.39FormulaC23H16F8N4O3
CAS number
2188236-41-9
Molecular weight
548.39
Formula
C23H16F8N4O3
Solubility
DMSO: 250 mg/mL (455·88 mM)
InChIKey
MVUPJRHPAMCBQJ-UHFFFAOYSA-N
Catalogue number
GC60592
Brand
GLPBIO
Computed properties PubChem CID 131953288 · XLogP 4.9 · TPSA 92.4 Ų · H-bond donors 3
XLogP
4.9
TPSA
92.4 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
6
Heavy atoms
38

SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=C(C=CC(=C3)C(C(F)(F)F)(C(F)(F)F)F)F

Computed descriptors from PubChem (CID 131953288), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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