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Chemical structure of APS-2-79

GC15240

APS-2-79

Also known as 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine;hydrochloride

APS-2-79 is a KSR-dependent MEK antagonist· APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM· APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling

ChemicalCAS2002381-31-7MW423.89FormulaC23H22ClN3O3
CAS number
2002381-31-7
Molecular weight
423.89
Formula
C23H22ClN3O3
Solubility
DMF： 10 mg/mL,DMSO： 25 mg/mL,DMSO：PBS (pH 7·2) (1：2)： 0·3 mg/mL,Ethanol： 1 mg/mL
InChIKey
LIXKSHWZJNNZHG-UHFFFAOYSA-N
Catalogue number
GC15240
Brand
GLPBIO
Computed properties PubChem CID 122177134 · TPSA 65.5 Ų · H-bond donors 2 · H-bond acceptors 6
TPSA
65.5 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl

Computed descriptors from PubChem (CID 122177134), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.