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Chemical structure of Apto-253

GC32692

Apto-253

Also listed as APTO-253 (LOR-253)

APTO-253 is a novel small molecule that exerts potent antitumor activity by inducing Kruppel-like factor 4(KLF4) master transcription factor gene expression, thereby inhibiting cell cycle and leading to programmed cell death

ChemicalCAS916151-99-0MW367.38FormulaC22H14FN5
CAS number
916151-99-0
Molecular weight
367.38
Formula
C22H14FN5
Solubility
DMSO : 33·33 mg/mL (90·72 mM);Water : < 0·1 mg/mL (insoluble)
InChIKey
NIRXBXIPHUTNNI-UHFFFAOYSA-N
Catalogue number
GC32692
Brand
GLPBIO
Computed properties PubChem CID 11960271 · XLogP 4.3 · TPSA 70.3 Ų · H-bond donors 2
XLogP
4.3
TPSA
70.3 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
28

SMILES CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6

Computed descriptors from PubChem (CID 11960271), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.