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Chemical structure of PROTAC RIPK degrader-2

GC60307

PROTAC RIPK degrader-2

Also known as (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinolin-7-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

PROTAC RIPK degrader-2 is a nonpeptidic PROTAC based on von Hippel-Lindau ligand which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation

ChemicalCAS1801547-16-9MW1060.31FormulaC52H65N7O11S3
CAS number
1801547-16-9
Molecular weight
1060.31
Formula
C52H65N7O11S3
InChIKey
RIEGJNXDHULIKM-GPPJZCFZSA-N
Catalogue number
GC60307
Brand
GLPBIO
Computed properties PubChem CID 91799297 · XLogP 5.9 · TPSA 295 Ų · H-bond donors 4
XLogP
5.9
TPSA
295 Ų
H-bond donors
4
H-bond acceptors
17
Rotatable bonds
26
Heavy atoms
73

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOC4=CC5=NC=CC(=C5C=C4S(=O)(=O)C(C)(C)C)NC6=CC7=C(C=C6)SC=N7)O

Computed descriptors from PubChem (CID 91799297), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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