GC60256
MRT199665
Also known as 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-[3-(pyrrolidin-1-ylmethyl)anilino]pyrrolo[2,3-d]pyrimidin-6-one
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively· MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells· MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370
ChemicalCAS1456858-57-3MW469.58FormulaC28H31N5O2
- CAS number
- 1456858-57-3
- Molecular weight
- 469.58
- Formula
- C28H31N5O2
- InChIKey
- OFIFLUFVENTCNZ-QHCPKHFHSA-N
- Catalogue number
- GC60256
- Brand
- GLPBIO
Computed properties PubChem CID 71725150 · XLogP 4.3 · TPSA 81.6 Ų · H-bond donors 2
- XLogP
- 4.3
- TPSA
- 81.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Rotatable bonds
- 5
- Heavy atoms
- 35
SMILES CC1(C2=CN=C(N=C2N(C1=O)[C@H]3CCC4=C3C=CC=C4O)NC5=CC=CC(=C5)CN6CCCC6)C
Computed descriptors from PubChem (CID 71725150), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il