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Chemical structure of GSK046

GC60182

GSK046

Also known as 4-acetamido-3-fluoro-N-(4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide

GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively

ChemicalCAS2474876-09-8MW414.47FormulaC23H27FN2O4
CAS number
2474876-09-8
Molecular weight
414.47
Formula
C23H27FN2O4
Solubility
DMSO ： 83·33 mg/mL (201·05 mM; Need ultrasonic)
InChIKey
FRBRZGLUFOZRGD-YCMKEVRSSA-N
Catalogue number
GC60182
Brand
GLPBIO
Computed properties PubChem CID 146018690 · XLogP 3 · TPSA 87.7 Ų · H-bond donors 3
XLogP
3
TPSA
87.7 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
30

SMILES C[C@@H](C1=CC=CC=C1)OC2=C(C(=CC(=C2)C(=O)NC3CCC(CC3)O)F)NC(=O)C

Computed descriptors from PubChem (CID 146018690), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.