GC12997
GSK J4 free base
Also known as ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
GSK J4 free base is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8·6 and 6·6 μM, respectively· GSK J4 free base inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM· GSK J4 is a cell permeable prodrug of GSK-J1· GSK J4 free base induces endoplasmic reticulum stress-related apoptosis
ChemicalCAS1373423-53-0MW417.46FormulaC24H27N5O2
- CAS number
- 1373423-53-0
- Molecular weight
- 417.46
- Formula
- C24H27N5O2
- Solubility
- ＜41·75mg/ml in DMSO; ＜41·75mg/ml in ethanol
- InChIKey
- WBKCKEHGXNWYMO-UHFFFAOYSA-N
- Catalogue number
- GC12997
- Brand
- GLPBIO
Computed properties PubChem CID 71729975 · XLogP 4.3 · TPSA 80.2 Ų · H-bond donors 1
- XLogP
- 4.3
- TPSA
- 80.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 8
- Heavy atoms
- 31
SMILES CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=CC=CC=C4CC3
Computed descriptors from PubChem (CID 71729975), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il