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Chemical structure of PF-6274484

GC44613

PF-6274484

Also known as N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide

PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0·18 and 0·14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively)

ChemicalCAS1035638-91-5MW372.8FormulaC18H14ClFN4O2
CAS number
1035638-91-5
Molecular weight
372.8
Formula
C18H14ClFN4O2
Solubility
DMF： 33 mg/ml,DMSO： 25 mg/ml
InChIKey
TUYDDIWQXWTNSW-UHFFFAOYSA-N
Catalogue number
GC44613
Brand
GLPBIO
Computed properties PubChem CID 74766099 · XLogP 3.9 · TPSA 76.1 Ų · H-bond donors 2
XLogP
3.9
TPSA
76.1 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
26

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=C

Computed descriptors from PubChem (CID 74766099), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.