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Chemical structure of PF-6683324

GC65009

PF-6683324

Also known as 2-[(3R,4S)-3-fluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy-5-(1-methylimidazol-4-yl)pyridine-3-carboxamide

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays withIC50s of 1·9 nM, 2·6 nM and 1·1 nM for TrkA, TrkB and TrkC, respectively

ChemicalCAS1799788-94-5MW521.46FormulaC24H23F4N5O4
CAS number
1799788-94-5
Molecular weight
521.46
Formula
C24H23F4N5O4
InChIKey
XJIIVPVOGYFVME-QUCCMNQESA-N
Catalogue number
GC65009
Brand
GLPBIO
Computed properties PubChem CID 118167692 · XLogP 2.7 · TPSA 113 Ų · H-bond donors 1
XLogP
2.7
TPSA
113 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
37

SMILES CN1C=C(N=C1)C2=CC(=C(N=C2)O[C@H]3CCN(C[C@H]3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N

Computed descriptors from PubChem (CID 118167692), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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