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Chemical structure of LP-533401

GC44083

LP-533401

Also known as (2S)-2-amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid

LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 μM

ChemicalCAS945976-43-2MW526.5FormulaC27H22F4N4O3
CAS number
945976-43-2
Molecular weight
526.5
Formula
C27H22F4N4O3
Solubility
DMF： 10 mg/ml,DMF：PBS(pH7·2) (1：2)： 0·33 mg/ml,DMSO： 5 mg/ml
InChIKey
JZWUKILTKYJLCN-XEGCMXMBSA-N
Catalogue number
GC44083
Brand
GLPBIO
Computed properties PubChem CID 44560455 · XLogP 2.9 · TPSA 124 Ų · H-bond donors 3
XLogP
2.9
TPSA
124 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
8
Heavy atoms
38

SMILES C1=CC(=CC(=C1)F)C2=CC=C(C=C2)C(C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)C[C@@H](C(=O)O)N)N

Computed descriptors from PubChem (CID 44560455), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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