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Chemical structure of Aurora Kinase Inhibitor II

GC40667

Aurora Kinase Inhibitor II

Also known as N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide

Aurora Kinase Inhibitor II is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively

ChemicalCAS331770-21-9MW400.4FormulaC23H20N4O3
CAS number
331770-21-9
Molecular weight
400.4
Formula
C23H20N4O3
Solubility
DMF: 0·25 mg/ml,DMF:PBS(pH7·2) (1:2): 0·33 mg/ml,DMSO: 2·5 mg/ml
InChIKey
IMYVCWQAHSYYOO-UHFFFAOYSA-N
Catalogue number
GC40667
Brand
GLPBIO
Computed properties PubChem CID 6610278 · XLogP 4.2 · TPSA 85.4 Ų · H-bond donors 2
XLogP
4.2
TPSA
85.4 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OC

Computed descriptors from PubChem (CID 6610278), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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