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Chemical structure of AMG8379

GC39696

AMG8379

Also known as 1-[4-(3-chloro-5-fluorophenyl)-5-fluoro-2-methoxyphenyl]-N-(1,2-oxazol-3-yl)-2-oxoquinoline-6-sulfonamide

AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1·7, with IC50s of 8·5 and 18·6 nM for hNaV1·7 and mNaV1·7, respectively

ChemicalCAS1642112-31-9MW543.93FormulaC25H16ClF2N3O5S
CAS number
1642112-31-9
Molecular weight
543.93
Formula
C25H16ClF2N3O5S
Solubility
Soluble in DMSO
InChIKey
HXQNEKJQBGXFAG-UHFFFAOYSA-N
Catalogue number
GC39696
Brand
GLPBIO
Computed properties PubChem CID 117737142 · XLogP 4.8 · TPSA 110 Ų · H-bond donors 1
XLogP
4.8
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
37

SMILES COC1=C(C=C(C(=C1)C2=CC(=CC(=C2)Cl)F)F)N3C4=C(C=CC3=O)C=C(C=C4)S(=O)(=O)NC5=NOC=C5

Computed descriptors from PubChem (CID 117737142), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.