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Chemical structure of YKL-5-124 TFA

GC39462

YKL-5-124 TFA

Also known as N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[[4-(prop-2-enoylamino)benzoyl]amino]-1,4-dihydropyrrolo[3,4-d]pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid

YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53·5 nM and 9·7 nM for CDK7 and CDK7/Mat1/CycH, respectively· YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13· YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status

ChemicalCAS2748220-93-9MW629.63FormulaC30H34F3N7O5
CAS number
2748220-93-9
Molecular weight
629.63
Formula
C30H34F3N7O5
Solubility
DMSO： ≥ 100 mg/mL (158·82 mM)
InChIKey
CPYGDECNKKKQGE-VZYDHVRKSA-N
Catalogue number
GC39462
Brand
GLPBIO
Computed properties PubChem CID 146025947 · TPSA 160 Ų · H-bond donors 5 · H-bond acceptors 10
TPSA
160 Ų
H-bond donors
5
H-bond acceptors
10
Rotatable bonds
8
Heavy atoms
45

SMILES CC1(C2=C(CN1C(=O)N[C@H](CN(C)C)C3=CC=CC=C3)C(=NN2)NC(=O)C4=CC=C(C=C4)NC(=O)C=C)C.C(=O)(C(F)(F)F)O

Computed descriptors from PubChem (CID 146025947), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.