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Chemical structure of YKL-06-061

GC37951

YKL-06-061

Also known as 1-cyclobutyl-3-(2,6-dimethylphenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one

YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6·56 nM/1·77 nM/20·5 nM for SIK1/2/3, respectively

ChemicalCAS2172617-15-9MW527.66FormulaC30H37N7O2
CAS number
2172617-15-9
Molecular weight
527.66
Formula
C30H37N7O2
Solubility
DMSO： 62·5 mg/mL (118·45 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
GVBAXIVNAHMIGH-UHFFFAOYSA-N
Catalogue number
GC37951
Brand
GLPBIO
Computed properties PubChem CID 132992144 · XLogP 4.5 · TPSA 77.1 Ų · H-bond donors 1
XLogP
4.5
TPSA
77.1 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
39

SMILES CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC

Computed descriptors from PubChem (CID 132992144), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.