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Chemical structure of MS21

GC69502

MS21

Also known as 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-[4-[11-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-11-oxoundecanoyl]piperazin-1-yl]propyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

MS21 is a novel AKT degrader that selectively inhibits the growth of mutant cancers through the PI3K/PTEN pathway

ChemicalCAS2376137-05-0MW1107.84FormulaC58H79ClN12O6S
CAS number
2376137-05-0
Molecular weight
1107.84
Formula
C58H79ClN12O6S
Solubility
Methanol ： 95 mg/mL (85·75 mM; Need ultrasonic)
InChIKey
UGJRTGFGCTUIRA-OBGAPNQASA-N
Catalogue number
GC69502
Brand
GLPBIO
Computed properties PubChem CID 155410583 · XLogP 7.1 · TPSA 263 Ų · H-bond donors 6
XLogP
7.1
TPSA
263 Ų
H-bond donors
6
H-bond acceptors
13
Rotatable bonds
24
Heavy atoms
78

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCC(=O)N4CCN(CC4)CC[C@@H](C5=CC=C(C=C5)Cl)NC(=O)C6(CCN(CC6)C7=NC=NC8=C7C=CN8)N)O

Computed descriptors from PubChem (CID 155410583), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.