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Chemical structure of GNF362

GC38916

GNF362

Also known as 4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]benzonitrile

GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC50 of 9 nM

ChemicalCAS1003019-41-7MW426.44FormulaC22H21F3N6
CAS number
1003019-41-7
Molecular weight
426.44
Formula
C22H21F3N6
Solubility
DMSO： 125 mg/mL (293·12 mM)
InChIKey
VNTCGXMLDSKOKN-OAHLLOKOSA-N
Catalogue number
GC38916
Brand
GLPBIO
Computed properties PubChem CID 57999583 · XLogP 3.6 · TPSA 71.8 Ų · H-bond donors 1
XLogP
3.6
TPSA
71.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
31

SMILES C[C@@H]1CN(CCN1C2=NC=C(C=C2)C(F)(F)F)CC3=C(NN=C3)C4=CC=C(C=C4)C#N

Computed descriptors from PubChem (CID 57999583), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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