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Chemical structure of GNF4877

GC38787

GNF4877

Also known as (3R)-1-[3-[[3-amino-6-(2-fluoro-5-propan-2-yloxyphenyl)pyrazine-2-carbonyl]amino]-4-pyridinyl]piperidine-3-carboxylic acid

GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0·66?μM for mouse β (R7T1) cells)

ChemicalCAS2041073-22-5MW494.52FormulaC25H27FN6O4
CAS number
2041073-22-5
Molecular weight
494.52
Formula
C25H27FN6O4
Solubility
DMSO： 4·17 mg/mL (8·43 mM and warming)
InChIKey
UZIATSFXNVOVFE-OAHLLOKOSA-N
Catalogue number
GC38787
Brand
GLPBIO
Computed properties PubChem CID 139600315 · XLogP 2.8 · TPSA 144 Ų · H-bond donors 3
XLogP
2.8
TPSA
144 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
36

SMILES CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCC[C@H](C4)C(=O)O)N

Computed descriptors from PubChem (CID 139600315), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.