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Chemical structure of TK216

GC38863

TK216

Also known as 4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one

TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor· TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions· TK216 blocks the binding between EWS-FLI1 and RNA helicase A· TK216 has anticancer activity

ChemicalCAS1903783-48-1MW376.23FormulaC19H15Cl2NO3
CAS number
1903783-48-1
Molecular weight
376.23
Formula
C19H15Cl2NO3
Solubility
DMSO： ≥ 250 mg/mL (664·49 mM)
InChIKey
ZWHNLSHDLKIXOG-UHFFFAOYSA-N
Catalogue number
GC38863
Brand
GLPBIO
Computed properties PubChem CID 121268274 · XLogP 4.1 · TPSA 66.4 Ų · H-bond donors 2
XLogP
4.1
TPSA
66.4 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
25

SMILES C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O

Computed descriptors from PubChem (CID 121268274), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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