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Chemical structure of Thalidomide-O-PEG2-propargyl

GC38861

Thalidomide-O-PEG2-propargyl

Also known as 2-(2,6-dioxopiperidin-3-yl)-4-[2-(2-prop-2-ynoxyethoxy)ethoxy]isoindole-1,3-dione

Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology

ChemicalCAS2098487-52-4MW400.38FormulaC20H20N2O7
CAS number
2098487-52-4
Molecular weight
400.38
Formula
C20H20N2O7
Solubility
Soluble in DMSO
InChIKey
XJWGDRINRIEEJD-UHFFFAOYSA-N
Catalogue number
GC38861
Brand
GLPBIO
Computed properties PubChem CID 131988624 · XLogP 0.1 · TPSA 111 Ų · H-bond donors 1
XLogP
0.1
TPSA
111 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
29

SMILES C#CCOCCOCCOC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Computed descriptors from PubChem (CID 131988624), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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