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Chemical structure of Thalidomide-NH-PEG2-COOH

GC61984

Thalidomide-NH-PEG2-COOH

Also known as 3-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]propanoic acid

Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology

ChemicalCAS2412056-45-0MW433.41FormulaC20H23N3O8
CAS number
2412056-45-0
Molecular weight
433.41
Formula
C20H23N3O8
Solubility
DMSO : 125 mg/mL (288·41 mM)
InChIKey
TWTMAVHRHZISKR-UHFFFAOYSA-N
Catalogue number
GC61984
Brand
GLPBIO
Computed properties PubChem CID 146410308 · XLogP -0.5 · TPSA 151 Ų · H-bond donors 3
XLogP
-0.5
TPSA
151 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
11
Heavy atoms
31

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCOCCOCCC(=O)O

Computed descriptors from PubChem (CID 146410308), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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