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Chemical structure of Pz-1

GC37047

Pz-1

Also known as N-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]acetamide

Pz-1 is a potent RET and VEGFR2 inhibitor with IC50s of less than 1 nM for both wild type kinases

ChemicalCAS1800505-64-9MW454.52FormulaC26H26N6O2
CAS number
1800505-64-9
Molecular weight
454.52
Formula
C26H26N6O2
Solubility
DMSO ： 50 mg/mL (110·01 mM; Need ultrasonic)
InChIKey
NJLMIILZNLZZFW-UHFFFAOYSA-N
Catalogue number
GC37047
Brand
GLPBIO
Computed properties PubChem CID 102004343 · XLogP 4.3 · TPSA 90.8 Ų · H-bond donors 1
XLogP
4.3
TPSA
90.8 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
34

SMILES CC(C)(C)C1=CC(=NO1)NC(=O)CC2=CC=C(C=C2)N3C=NC4=C3C=CC(=C4)C5=CN(N=C5)C

Computed descriptors from PubChem (CID 102004343), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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