Loading...
Chemical structure of Py-MAA-Val-Cit-PAB-MMAE

GC69783

Py-MAA-Val-Cit-PAB-MMAE

Also known as [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[[2-[3-[3,5-di(prop-2-enoyl)-1,3,5-triazinan-1-yl]-3-oxopropyl]sulfanylacetyl]amino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate

Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) is an ADC linker used to synthesize Zapadcine-3a (ADC)· Zapadcine-3a has broad-spectrum anti-tumor activity· It targets TRAILR2 and is engulfed by tumor cell lysosomes, releasing small molecule compounds to specifically kill TRAILR2-positive tumors· Zapadcine-3a efficiently eliminates tumor cells and cures tumors

ChemicalCAS2247398-68-9MW1446.79FormulaC72H111N13O16S
CAS number
2247398-68-9
Molecular weight
1446.79
Formula
C72H111N13O16S
Solubility
DMSO ： 100 mg/mL (69·12 mM; Need ultrasonic)
InChIKey
ASDXMJBJAKMFHO-NGASZDMPSA-N
Catalogue number
GC69783
Brand
GLPBIO
Computed properties PubChem CID 146572802 · XLogP 5 · TPSA 396 Ų · H-bond donors 8
XLogP
5
TPSA
396 Ų
H-bond donors
8
H-bond acceptors
17
Rotatable bonds
40
Heavy atoms
102

SMILES CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CSCCC(=O)N4CN(CN(C4)C(=O)C=C)C(=O)C=C

Computed descriptors from PubChem (CID 146572802), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.