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Chemical structure of Pz-Pro-Leu-Gly-Pro-D-Arg-OH

GA23436

Pz-Pro-Leu-Gly-Pro-D-Arg-OH

Also known as (2R)-5-(diaminomethylideneamino)-2-[[(2S)-1-[2-[[(2S)-4-methyl-2-[[(2S)-1-[(4-phenyldiazenylphenyl)methoxycarbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]pentanoic acid

Chromogenic substrate for the assay of collagenase and thimet oligopeptidase (Pz-peptidase, metalloendopeptidase 24·15, collagenase-like peptidase)· Enzymatic cleavage yields Pz-Pro-Leu-OH, G-2970 (or Pz-Pro-OH, E-2275)· The cleavage can be monitored by analytical HPLC, detection at 320 nm

ChemicalCAS17011-78-8MW776.89FormulaC38H52N10O8
CAS number
17011-78-8
Molecular weight
776.89
Formula
C38H52N10O8
Solubility
Soluble in DMSO
InChIKey
WLJYNHBZKOQNNI-BHSUFKTOSA-N
Catalogue number
GA23436
Brand
GLPBIO
Computed properties PubChem CID 161208 · XLogP 2.5 · TPSA 264 Ų · H-bond donors 6
XLogP
2.5
TPSA
264 Ų
H-bond donors
6
H-bond acceptors
11
Rotatable bonds
19
Heavy atoms
56

SMILES CC(C)C[C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)OCC3=CC=C(C=C3)N=NC4=CC=CC=C4

Computed descriptors from PubChem (CID 161208), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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