Loading...
Chemical structure of MPT0B392

GC36652

MPT0B392

Also known as 6-methoxy-2-(3,4,5-trimethoxyphenyl)sulfonylquinolin-5-amine

MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis· MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis· MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line

ChemicalCAS1346169-92-3MW404.44FormulaC19H20N2O6S
CAS number
1346169-92-3
Molecular weight
404.44
Formula
C19H20N2O6S
Solubility
Soluble in DMSO
InChIKey
RBBRZMLZQCYQJM-UHFFFAOYSA-N
Catalogue number
GC36652
Brand
GLPBIO
Computed properties PubChem CID 56834893 · XLogP 2.5 · TPSA 118 Ų · H-bond donors 1
XLogP
2.5
TPSA
118 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
28

SMILES COC1=C(C2=C(C=C1)N=C(C=C2)S(=O)(=O)C3=CC(=C(C(=C3)OC)OC)OC)N

Computed descriptors from PubChem (CID 56834893), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.