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Chemical structure of Larotrectinib

GC36425

Larotrectinib

Also listed as LOXO-101 (Larotrectinib)

LOXO-101 (Larotrectinib) (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C)

ChemicalCAS1223403-58-4MW428.44FormulaC21H22F2N6O2
CAS number
1223403-58-4
Molecular weight
428.44
Formula
C21H22F2N6O2
Solubility
DMSO： ≥ 4·6 mg/mL (10·74 mM)
InChIKey
NYNZQNWKBKUAII-KBXCAEBGSA-N
Catalogue number
GC36425
Brand
GLPBIO
Computed properties PubChem CID 46188928 · XLogP 1.7 · TPSA 86 Ų · H-bond donors 2
XLogP
1.7
TPSA
86 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
31

SMILES C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F

Computed descriptors from PubChem (CID 46188928), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.