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Chemical structure of LOXO-292

GC19547

LOXO-292

Also known as 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

LOXO-292 (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14·0 nM, 24·1 nM, and 530·7 nM for RET (WT), RET (V804M), and RET (G810R), respectively· LOXO-292 has anticancer activity

ChemicalCAS2152628-33-4MW525.613FormulaC29H31N7O3
CAS number
2152628-33-4
Molecular weight
525.613
Formula
C29H31N7O3
Solubility
DMF： 1 mg/ml,DMSO： 1 mg/ml
InChIKey
XIIOFHFUYBLOLW-UHFFFAOYSA-N
Catalogue number
GC19547
Brand
GLPBIO
Computed properties PubChem CID 134436906 · XLogP 2.5 · TPSA 112 Ų · H-bond donors 1
XLogP
2.5
TPSA
112 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
39

SMILES CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O

Computed descriptors from PubChem (CID 134436906), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.