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Chemical structure of GSK3368715 dihydrochloride

GC36192

GSK3368715 dihydrochloride

Also known as N'-[[5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl]methyl]-N,N'-dimethylethane-1,2-diamine;dihydrochloride

GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3·1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5·7 nM (PRMT6), 1·7 nM (PRMT8))· GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity

ChemicalCAS1628925-77-8MW439.46FormulaC20H40Cl2N4O2
CAS number
1628925-77-8
Molecular weight
439.46
Formula
C20H40Cl2N4O2
Solubility
DMSO： 250 mg/mL (568·88 mM)
InChIKey
HPSRPMOJFMXEKS-UHFFFAOYSA-N
Catalogue number
GC36192
Brand
GLPBIO
Computed properties PubChem CID 138911351 · TPSA 62.4 Ų · H-bond donors 4 · H-bond acceptors 5
TPSA
62.4 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
12
Heavy atoms
28

SMILES CCOCC1(CCC(CC1)C2=C(C=NN2)CN(C)CCNC)COCC.Cl.Cl

Computed descriptors from PubChem (CID 138911351), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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