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Chemical structure of Cot inhibitor-2

GC35735

Cot inhibitor-2

Also known as 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1·6 nM· Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0·3 μM

ChemicalCAS915363-56-3MW539.43FormulaC26H25Cl2FN8
CAS number
915363-56-3
Molecular weight
539.43
Formula
C26H25Cl2FN8
Solubility
DMSO： ≥ 100 mg/mL (185·38 mM)
InChIKey
PHNZIIMWDVXPGG-UHFFFAOYSA-N
Catalogue number
GC35735
Brand
GLPBIO
Computed properties PubChem CID 44143370 · XLogP 5.5 · TPSA 94.7 Ų · H-bond donors 2
XLogP
5.5
TPSA
94.7 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
37

SMILES CCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl

Computed descriptors from PubChem (CID 44143370), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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