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Chemical structure of Cot inhibitor-1

GC35734

Cot inhibitor-1

Also known as 6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM

ChemicalCAS915365-57-0MW553.46FormulaC27H27Cl2FN8
CAS number
915365-57-0
Molecular weight
553.46
Formula
C27H27Cl2FN8
Solubility
DMSO： 25 mg/mL (45·17 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
ZWFKJFUFYPOTKL-UHFFFAOYSA-N
Catalogue number
GC35734
Brand
GLPBIO
Computed properties PubChem CID 11584834 · XLogP 5.8 · TPSA 94.7 Ų · H-bond donors 2
XLogP
5.8
TPSA
94.7 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
38

SMILES C1CCCN(CC1)CCN2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl

Computed descriptors from PubChem (CID 11584834), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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