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Cot (phospho Ser400) Polyclonal Antibody

13955

Cot (phospho Ser400) Polyclonal Antibody

Cot (phospho Ser400) Polyclonal Antibody (catalogue number 13955) is a rabbit-derived primary antibody validated for IHC-p, IF(paraffin section), ELISA, reactive with Human, Mouse, Rat samples. It targets Mitogen-activated protein kinase kinase kinase 8 (MAP3K8): Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Supplied in 2 pack sizes, from 50ul at ₪893.28 to 100ul at ₪1,301.17; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC-p IF(paraffin section) ELISA
UniProt ID
P41279
Gene
MAP3K8
Target organism
Homo sapiens
Catalogue number
13955
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) · Homo sapiens

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4.

Subcellular location: Cytoplasm

Tissue specificity: Expressed in several normal tissues and human tumor-derived cell lines

Sequence length: 467 aa · 52925 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.