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Chemical structure of AX-024

GC35440

AX-024

Also known as 1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine

AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM

ChemicalCAS1370544-73-2MW339.4FormulaC21H22FNO2
CAS number
1370544-73-2
Molecular weight
339.4
Formula
C21H22FNO2
Solubility
Ethanol： 100 mg/mL (294·64 mM); DMSO： 35 mg/mL (103·12 mM and warming); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
VMMKGVRPILDZML-UHFFFAOYSA-N
Catalogue number
GC35440
Brand
GLPBIO
Computed properties PubChem CID 56949412 · XLogP 3.4 · TPSA 21.7 Ų · H-bond donors 0
XLogP
3.4
TPSA
21.7 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
25

SMILES COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4

Computed descriptors from PubChem (CID 56949412), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.