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Chemical structure of AV-412

GC35435

AV-412

Also known as N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide;bis(4-methylbenzenesulfonic acid)

A dual inhibitor of EGFR and HER2

ChemicalCAS451493-31-5MW851.41FormulaC41H44ClFN6O7S2
CAS number
451493-31-5
Molecular weight
851.41
Formula
C41H44ClFN6O7S2
Solubility
DMSO： ≥ 28 mg/mL (32·89 mM)
InChIKey
GTWJVFFZCKODEV-UHFFFAOYSA-N
Catalogue number
GC35435
Brand
GLPBIO
Computed properties PubChem CID 11700696 · TPSA 199 Ų · H-bond donors 4 · H-bond acceptors 13
TPSA
199 Ų
H-bond donors
4
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
58

SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C

Computed descriptors from PubChem (CID 11700696), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.