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Chemical structure of VL285

GC34855

VL285

Also known as (2S,4R)-4-hydroxy-1-[(2S)-3-methyl-2-(3-oxo-1H-isoindol-2-yl)butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

VL285 is a potent VHL ligand with an IC50 of 0·34 μM

ChemicalCAS1448188-57-5MW532.65FormulaC29H32N4O4S
CAS number
1448188-57-5
Molecular weight
532.65
Formula
C29H32N4O4S
Solubility
DMSO ： 125 mg/mL (234·68 mM)
InChIKey
HEDFFPYRFJKXQP-VJTSUQJLSA-N
Catalogue number
GC34855
Brand
GLPBIO
Computed properties PubChem CID 71667162 · XLogP 3.3 · TPSA 131 Ų · H-bond donors 2
XLogP
3.3
TPSA
131 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
38

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)C)N4CC5=CC=CC=C5C4=O)O

Computed descriptors from PubChem (CID 71667162), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.