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Chemical structure of GSK-843

GC34606

GSK-843

Also known as 3-(1,3-benzothiazol-5-yl)-7-(2,5-dimethylpyrazol-3-yl)thieno[3,2-c]pyridin-4-amine

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8·6 nM, and inhibits kinase activity with an IC50 of 6·5 nM

ChemicalCAS1601496-05-2MW377.49FormulaC19H15N5S2
CAS number
1601496-05-2
Molecular weight
377.49
Formula
C19H15N5S2
Solubility
DMSO ： 50 mg/mL (132·45 mM; Need ultrasonic)
InChIKey
BPKSNNJTKPIZKR-UHFFFAOYSA-N
Catalogue number
GC34606
Brand
GLPBIO
Computed properties PubChem CID 91885439 · XLogP 4 · TPSA 126 Ų · H-bond donors 1
XLogP
4
TPSA
126 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
26

SMILES CC1=NN(C(=C1)C2=CN=C(C3=C2SC=C3C4=CC5=C(C=C4)SC=N5)N)C

Computed descriptors from PubChem (CID 91885439), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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