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Chemical structure of ACY-1083

GC34458

ACY-1083

Also known as 2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms· ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy

ChemicalCAS1708113-43-2MW348.35FormulaC17H18F2N4O2
CAS number
1708113-43-2
Molecular weight
348.35
Formula
C17H18F2N4O2
Solubility
DMSO： 100 mg/mL (287·07 mM)
InChIKey
MRWCVKLVSWYIFO-UHFFFAOYSA-N
Catalogue number
GC34458
Brand
GLPBIO
Computed properties PubChem CID 91844718 · XLogP 2.5 · TPSA 87.1 Ų · H-bond donors 3
XLogP
2.5
TPSA
87.1 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
25

SMILES C1CC(CCC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO)(F)F

Computed descriptors from PubChem (CID 91844718), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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