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Chemical structure of ACY-957

GC30526

ACY-957

Also known as N-(2-amino-5-thiophen-2-ylphenyl)-2-piperazin-1-ylquinoline-6-carboxamide

ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9

ChemicalCAS1609389-52-7MW429.54FormulaC24H23N5OS
CAS number
1609389-52-7
Molecular weight
429.54
Formula
C24H23N5OS
Solubility
DMSO ： 83·33 mg/mL (194·00 mM)
InChIKey
VURDNNVAYZDGDK-UHFFFAOYSA-N
Catalogue number
GC30526
Brand
GLPBIO
Computed properties PubChem CID 72374405 · XLogP 3.5 · TPSA 112 Ų · H-bond donors 3
XLogP
3.5
TPSA
112 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
31

SMILES C1CN(CCN1)C2=NC3=C(C=C2)C=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N

Computed descriptors from PubChem (CID 72374405), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.