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Chemical structure of ARS-1620

GC34055

ARS-1620

Also known as 1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one

ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics

ChemicalCAS1698055-85-4MW430.84FormulaC21H17ClF2N4O2
CAS number
1698055-85-4
Molecular weight
430.84
Formula
C21H17ClF2N4O2
Solubility
DMSO : ≥ 53 mg/mL (123·02 mM)
InChIKey
ZRPZPNYZFSJUPA-UHFFFAOYSA-N
Catalogue number
GC34055
Brand
GLPBIO
Computed properties PubChem CID 137003167 · XLogP 4 · TPSA 69.6 Ų · H-bond donors 1
XLogP
4
TPSA
69.6 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
30

SMILES C=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F

Computed descriptors from PubChem (CID 137003167), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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