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Chemical structure of ART558

GC62553

ART558

Also known as (2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)pyrrolidine-2-carboxamide

ART558 is a potent and selective low-molecular-weight allosteric inhibitor of DNA polymerase Polθ, with a molecular weight (MW) in the nanomolar range and an IC50 of 7·9 nM

ChemicalCAS2603528-97-6MW418.41FormulaC21H21F3N4O2
CAS number
2603528-97-6
Molecular weight
418.41
Formula
C21H21F3N4O2
Solubility
85 mg/mL in DMSO(Need ultrasonic)
InChIKey
YHMDHAMZFMNMTF-MSOLQXFVSA-N
Catalogue number
GC62553
Brand
GLPBIO
Computed properties PubChem CID 156068882 · XLogP 3.9 · TPSA 80.5 Ų · H-bond donors 1
XLogP
3.9
TPSA
80.5 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
30

SMILES CC1=CC(=CC=C1)N(C)C(=O)[C@@H]2[C@@H](CCN2C3=NC(=CC(=C3C#N)C(F)(F)F)C)O

Computed descriptors from PubChem (CID 156068882), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.