Loading...
Chemical structure of TAS-116

GC33286

TAS-116

Also known as 3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide

TAS-116 (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34·7 nM and 21·3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94· TAS-116 demonstrates less ocular toxicity

ChemicalCAS1260533-36-5MW454.53FormulaC25H26N8O
CAS number
1260533-36-5
Molecular weight
454.53
Formula
C25H26N8O
Solubility
DMSO： 125 mg/mL (275·01 mM)
InChIKey
NVVPMZUGELHVMH-UHFFFAOYSA-N
Catalogue number
GC33286
Brand
GLPBIO
Computed properties PubChem CID 67501411 · XLogP 3.1 · TPSA 109 Ų · H-bond donors 1
XLogP
3.1
TPSA
109 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
34

SMILES CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C

Computed descriptors from PubChem (CID 67501411), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.