Loading...
Chemical structure of M443

GC33260

M443

Also known as 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(1-prop-2-enoylpiperidin-3-yl)pyrimidin-2-yl]amino]benzamide

M443 is an irreversible and specific inhibitor of MRK, with an IC50＜125 nM

ChemicalCAS1820684-31-8MW589.61FormulaC31H30F3N7O2
CAS number
1820684-31-8
Molecular weight
589.61
Formula
C31H30F3N7O2
Solubility
DMSO ： 55 mg/mL (93·28 mM)
InChIKey
QAQFNUYJUCJMKF-UHFFFAOYSA-N
Catalogue number
GC33260
Brand
GLPBIO
Computed properties PubChem CID 92042851 · XLogP 5 · TPSA 105 Ų · H-bond donors 2
XLogP
5
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
43

SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5CCCN(C5)C(=O)C=C

Computed descriptors from PubChem (CID 92042851), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.