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Chemical structure of Rhosin

GC33167

Rhosin

Also known as (2R)-2-amino-3-(1H-indol-3-yl)-N-[(E)-quinoxalin-6-ylmethylideneamino]propanamide

Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0·4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG· Rhosin induces cell apoptosis· Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability

ChemicalCAS1173671-63-0MW358.4FormulaC20H18N6O
CAS number
1173671-63-0
Molecular weight
358.4
Formula
C20H18N6O
Solubility
Soluble in DMSO
InChIKey
FGYHLIHEFHCMPP-FVWOBLMASA-N
Catalogue number
GC33167
Brand
GLPBIO
Computed properties PubChem CID 9552914 · XLogP 1.7 · TPSA 109 Ų · H-bond donors 3
XLogP
1.7
TPSA
109 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
27

SMILES C1=CC=C2C(=C1)C(=CN2)C[C@H](C(=O)N/N=C/C3=CC4=NC=CN=C4C=C3)N

Computed descriptors from PubChem (CID 9552914), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.