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Chemical structure of Rho-Kinase-IN-2

GC66050

Rho-Kinase-IN-2

Also known as (2R)-4-(3-fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide

Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM)· Rho-Kinase-IN-2 can be used in Huntington's research

ChemicalCAS2573071-18-6MW372.44FormulaC20H25FN4O2
CAS number
2573071-18-6
Molecular weight
372.44
Formula
C20H25FN4O2
Solubility
DMSO ： 50 mg/mL (134·25 mM; Need ultrasonic)
InChIKey
CIPXFTLGPVQJKN-HUUCEWRRSA-N
Catalogue number
GC66050
Brand
GLPBIO
Computed properties PubChem CID 155749520 · XLogP 2.5 · TPSA 57.7 Ų · H-bond donors 1
XLogP
2.5
TPSA
57.7 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
27

SMILES C[C@@H]1CN(CCN1C(=O)N[C@H](C)C2=CC(=CC=C2)OC)C3=C(C=NC=C3)F

Computed descriptors from PubChem (CID 155749520), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.