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Chemical structure of Akt1 and Akt2-IN-1

GC32939

Akt1 and Akt2-IN-1

Also known as 3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3·5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity

ChemicalCAS893422-47-4MW539.63FormulaC33H29N7O
CAS number
893422-47-4
Molecular weight
539.63
Formula
C33H29N7O
Solubility
DMSO ： ≥ 35 mg/mL (64·86 mM)
InChIKey
BTUWHHFNOHVCMQ-UHFFFAOYSA-N
Catalogue number
GC32939
Brand
GLPBIO
Computed properties PubChem CID 11656753 · XLogP 4.4 · TPSA 99.7 Ų · H-bond donors 2
XLogP
4.4
TPSA
99.7 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
41

SMILES C1CN(CCC1C2=NC(=NN2)C3=CC=CC=N3)CC4=CC=C(C=C4)C5=C(C=C6C(=N5)C=CNC6=O)C7=CC=CC=C7

Computed descriptors from PubChem (CID 11656753), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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