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Chemical structure of Ilginatinib (NS-018)

GC32809

Ilginatinib (NS-018)

Also known as 6-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine

Ilginatinib (NS-018) (NS-018) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0·72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM)

ChemicalCAS1239358-86-1MW389.43FormulaC21H20FN7
CAS number
1239358-86-1
Molecular weight
389.43
Formula
C21H20FN7
Solubility
DMSO ： ≥ 34 mg/mL (87·31 mM)
InChIKey
UQTPDWDAYHAZNT-AWEZNQCLSA-N
Catalogue number
GC32809
Brand
GLPBIO
Computed properties PubChem CID 46866319 · XLogP 3.2 · TPSA 80.6 Ų · H-bond donors 2
XLogP
3.2
TPSA
80.6 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
29

SMILES C[C@@H](C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C

Computed descriptors from PubChem (CID 46866319), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.