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Chemical structure of GCN2iB

GC32739

GCN2iB

Also known as N-[3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxypyridine-3-sulfonamide

GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2·4 nM

ChemicalCAS2183470-12-2MW451.83FormulaC18H12ClF2N5O3S
CAS number
2183470-12-2
Molecular weight
451.83
Formula
C18H12ClF2N5O3S
Solubility
DMSO ： 16·67 mg/mL (36·89 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
JGHVXJKGYJYWOP-UHFFFAOYSA-N
Catalogue number
GC32739
Brand
GLPBIO
Computed properties PubChem CID 134814489 · XLogP 2.5 · TPSA 128 Ų · H-bond donors 2
XLogP
2.5
TPSA
128 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
30

SMILES COC1=C(C=C(C=N1)Cl)S(=O)(=O)NC2=C(C(=C(C=C2)F)C#CC3=CN=C(N=C3)N)F

Computed descriptors from PubChem (CID 134814489), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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