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Chemical structure of GCN2-IN-6

GC39384

GCN2-IN-6

Also known as N-[3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl]-2,5-dichloro-3-(hydroxymethyl)benzenesulfonamide

GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1·8 nM) and cellular assays (IC50 of 9·3 nM)· GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0·26 nM (in enzymatic assay) and 230 nM (in cells)

ChemicalCAS2183470-09-7MW485.29FormulaC19H12Cl2F2N4O3S
CAS number
2183470-09-7
Molecular weight
485.29
Formula
C19H12Cl2F2N4O3S
Solubility
DMSO： 250 mg/mL (515·16 mM)
InChIKey
VJXAWOQPYMAEFQ-UHFFFAOYSA-N
Catalogue number
GC39384
Brand
GLPBIO
Computed properties PubChem CID 137347437 · XLogP 3 · TPSA 127 Ų · H-bond donors 3
XLogP
3
TPSA
127 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
31

SMILES C1=CC(=C(C(=C1NS(=O)(=O)C2=CC(=CC(=C2Cl)CO)Cl)F)C#CC3=CN=C(N=C3)N)F

Computed descriptors from PubChem (CID 137347437), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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