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Chemical structure of GCN2-IN-1 (A-92)

GC32771

GCN2-IN-1 (A-92)

Also known as 3-(1H-indazol-6-yl)-N-[1-(oxan-4-yl)pyrazol-4-yl]triazolo[4,5-d]pyrimidin-5-amine

GCN2-IN-1 (A-92) (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of ＜0·3 μM in the enzyme assay and an IC50 of 0·3-3 μM in the cell assay

ChemicalCAS1448693-69-3MW402.41FormulaC19H18N10O
CAS number
1448693-69-3
Molecular weight
402.41
Formula
C19H18N10O
Solubility
DMSO ： 60 mg/mL (149·10 mM)
InChIKey
CFNFLNGJQOHNPR-UHFFFAOYSA-N
Catalogue number
GC32771
Brand
GLPBIO
Computed properties PubChem CID 89720372 · XLogP 1.5 · TPSA 124 Ų · H-bond donors 2
XLogP
1.5
TPSA
124 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
30

SMILES C1COCCC1N2C=C(C=N2)NC3=NC=C4C(=N3)N(N=N4)C5=CC6=C(C=C5)C=NN6

Computed descriptors from PubChem (CID 89720372), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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